I think that is indeed true for most of their plugins. I have no idea what their Keylight expects but I know that if you use ACES to go to linear you have to flip these switches to prevent a double convert.
If you have a hybrid ACES setup in AE with color management enabled and linearize working space checked you don’t have to do those switches and maybe other plugins will behave differently too but I’ve never tested that.
These are the only effects that I know of that give you that option though. In general all 32bit plugins should somewhat support what you’re trying to do but the parameter ranges might be made for “video” making it possibly difficult to finetune in linear space.
In those cases I would indeed create a sandwich for those effects.