I guess it depends where you are doing the key, if, for example, you stay in Nuke, you should only suffer from a minimal quality loss that will not be perceptible. You would basically apply a ColorMatrix node to convert from ACEScg to ALEXA Wide Gamut, perform your key and convert back to ACEScg.
yea rhats what I thought, practially i then need to make sure I have knowledge about the source primaries of the camera then as well, lot of the times we get EXR turnovers that are aces-2065 allready , but I guess just going to something really large and then back should be fine in any case.
Maybe you could lift the image just enought for the negative values to be positive, do your key and move it lift it back down to the original image. That’s what I have done a few times when I got negative values in ACEScg.